Defining Cancer

Cancer is a term for diseases in which abnormal cells divide without control and can invade other tissues. Cancer cells can spread to other parts of the body through the blood and lymph systems.

Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. The main categories of cancer include:

• Carcinoma - cancer that begins in the skin or in tissues that line or cover internal organs.
• Sarcoma - cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue.
• Leukemia - cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of abnormal blood cells to be produced and enter the blood.
• Lymphoma and myeloma - cancers that begin in the cells of the immune system.
• Central nervous system cancers - cancers that begin in the tissues of the brain and spinal cord.

(For definitions of other cancer-related terms, see NCI's Dictionary of Cancer Terms.)

Origins of Cancer

All cancers begin in cells, the body's basic unit of life. To understand cancer, it's helpful to know what happens when normal cells become cancer cells.

The body is made up of many types of cells. These cells grow and divide in a controlled way to produce more cells as they are needed to keep the body healthy. When cells become old or damaged, they die and are replaced with new cells.

But sometimes this orderly process goes wrong. The genetic material (DNA) of a cell can become damaged or changed, producing mutations that affect normal cell growth and division. When this happens, cells do not die when they should and new cells form when the body does not need them. The extra cells may form a mass of tissue called a tumor.

(Image from Understanding Cancer Series: Cancer.)

Not all tumors are cancerous; tumors can be benign or malignant.

• Benign tumors aren't cancerous. They can often be removed, and, in most cases, they do not come back. Cells in benign tumors do not spread to other parts of the body.
• Malignant tumors are cancerous. Cells in these tumors can invade nearby tissues and spread to other parts of the body. The spread of cancer from one part of the body to another is called metastasis.

Most cancers are named for the organ or type of cell in which they begin. For example, cancer that begins in the stomach is called stomach cancer.

Some cancers do not form tumors. For example, leukemia is a cancer of the bone marrow and blood.

Cancer Statistics

A new report from the nation's leading cancer organizations shows cancer death rates decreased on average 2.1 percent per year from 2002 through 2004, nearly twice the annual decrease of 1.1 percent per year from 1993 through 2002. (Read more about the Annual Report.)

Estimated new cases and deaths from cancer in the United States in 2007:

• New cases: 1,444,920 (does not include nonmelanoma skin cancers)
• Deaths: 559,650

NCI's Cancer Stat Fact Sheets provide frequently requested cancer statistics for a number of cancer types.

Adapted from article by National Cancer Institute of US www.cancer.gov